Accutane (isotretinoin) is a systemic retinoid that reduces sebaceous gland size and markedly decreases sebum production. It normalizes follicular keratinization, which helps prevent comedone formation and follicular obstruction. The drug also exhibits anti-inflammatory effects and indirectly reduces the population of Cutibacterium acnes by altering the skin environment. Through these combined mechanisms, Accutane targets all major pathogenic factors involved in severe acne. You can buy Accutane in the USA online without a prescription on the website skin-care-meds.com.